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. 2021 Jul 23;22(11):733–750. doi: 10.1038/s41580-021-00392-4

Fig. 4. Deregulated autophagosome maturation in neurodegenerative diseases.

Fig. 4

Illustration of endolysosome trafficking and the progression of autophagosomes into autolysosomes. Impairments of several steps in the process have been linked to the pathogenesis of neurodegenerative diseases, and examples of the related diseases are shown. AD, Alzheimer disease; ALS, amyotrophic lateral sclerosis; BPAN, β-propeller protein-associated neurodegeneration; FTD, frontotemporal dementia; HD, Huntington disease; ID, intellectual disability; LSD, lysosomal storage disease; MLIV, mucolipidosis type IV; MPSIIIA, mucopolysaccharidosis type IIIA; MSD, multiple sulfatase deficiency; PD, Parkinson disease; poly(Q)-AR, androgen receptor with polyglutamine expansion; poly(Q)-HTT, huntingtin with polyglutamine expansion; SBMA, spinal and bulbar muscular atrophy.