Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 25;144(4):286–302. doi: 10.1161/CIRCULATIONAHA.120.052318

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

PMC Copyright notice

Figure 2. — Assessing coarse-granular endothelial heterogeneity of the human lung by single-cell RNA sequencing. Heat map of marker genes for all 29 non–endothelial cell (EC) cell types and of lymphatic cells as well as panendothelial (specifically expressed in all 6 EC populations) and panvascular (specifically expressed in all EC populations except lymphatic ECs) marker genes. Cell types were grouped into lineages and lineage marker genes are shown at the top of the heat map to the right. Then, 2 marker genes per non-EC cell type are shown, followed by a focus on ECs. The heat map to the left zooms in on the gene expression of ECs and depicts, from top to bottom, sets of lymphatic, panendothelial, and panvascular marker genes in the 6 endothelial populations. Each column represents the average expression value for 1 participant, grouped by cell type and cohort. All gene expression values are unity normalized from 0 to 1 across rows. For an enlarged heat map of non-EC cell types, see Figure I in the Data Supplement. TGen indicates Translational Genomics Research Institute; VIB, Leuven Vlaams Instituut voor Biotechnologie; and WSI, Wellcome Sanger Institute.