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. 2021 May 25;144(4):286–302. doi: 10.1161/CIRCULATIONAHA.120.052318

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© 2021 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 6. — Endothelial cell (EC)–focused intercellular communication. Visualization of a small subset of the connectomic analysis. Circos plots of top 75 edges by edge weight with EC subpopulations as (A) senders and (B) receivers. Edge thickness is proportional to edge weights. Edge color labels the source cell type. In both Circos plots, ligands occupy the lower semicircle and corresponding receptors the upper semicircle, and ligands and receptors are colored by the expressing cell type. The full results of the connectomic analysis can be found in Table VI. AM indicates alveolar macrophage; AT1/2, alveolar cell type 1/2; cDC1/2, classical dendritic cell type 1/2; cMono, classical monocyte; DC, dendritic cell; ILC, innate lymphoid cell; M, macrophage; ncMono, nonclassical monocyte; NK, natural killer; pDC, plasmacytoid dendritic cell; PNEC, pulmonary neuroendocrine cell; scRNAseq, single cell RNA sequencing; and SMC, smooth muscle cell.