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. 2021 Jun 28;11(7):1915. doi: 10.3390/ani11071915

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Schematic diagram summarizing the mechanisms underlying the hepatoprotective and oviprotective effects of the combination of quercetin and vitamin E to promote follicle formation and attenuate oxidative stress, inflammation, and apoptosis in aging breeder hens. Supplementation of quercetin + vitamin E promotes the synthesis and expression of reproductive hormones and their receptors, and up-regulates the transcriptions related to vitellogenesis and lipogenesis via the liver–blood–ovary signal axis in aging breeder hens.