Abstract
The main purpose of the present study was to see if a kinetic model and a computer program for characterizing the rate of uptake and clearance of chemicals in aquatic organisms (Biofac, OECD’s Chemicals Testing Programme) was applicable to pharmacokinetic studies in fish. The program seems suitable for such studies.
The effect of temperature upon rate of absorption of sulphadimidine from medicated water and elimination of the same drug was investigated in rainbow trout. A rise in the temperature from 7° C to 14° C more than doubled the calculated rate constants of absorption and elimination. The biological half life (t½ β) and the time to reach 90 % of steady state (t90% ss) at 14° C were approximately half the values at 7° C.
Keywords: absorption, elimination, pharmacokinetic parameters, fish, drug, temperature, computer program
Sammendrag
Hensikten med dette forsøket var å undersøke om den kinetiske modellen som er anbefalt av OEGD’s Chemicals Testing Programme er anvendbar på farmakokinetiske studier på fisk. Til denne modellen er det skrevet et computerprogram (Biofac) som beregner hastighetskonstantene for opptak og utskillelse av kjemikalier i organismer i vann. Programmet synes å passe til studier av denne type, men konstante forsøksbetingelser er avgjørende for å oppnå god tilpasning til modellen.
Temperaturens inn virkning på absorpsjonen av sulfadimidin fra vann og eliminasjonen av samme stoff ble undersøkt for regnbueørret. En heving av temperaturen fra 7° C til 14° G gav mer enn fordobling av kalkulerte hastighetskonstanter for absorpsjon og eliminasjon. Halveringstid (t½ β) og tid for oppnådd 90 % av steady state (t90% ss) var omtrent halvert ved 14° C sammenlignet med 7° C.
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