Table 2. Multivariate analysis of CXCL12 expression for overall survival in the TCGA cohorts.
| Variables | Whole-AML (n = 173) | CN-AML (n = 80) | ||
|---|---|---|---|---|
| Hazard Ratio (95% CI) | P | Hazard Ratio (95% CI) | P | |
| CXCL12a | 2.25 [1.51–3.35] | <0.0001 | 2.14 [1.15–3.97] | 0.016 |
| Ageb | 1.01 [1.00–1.03] | <0.0001 | 2.37 [1.35–4.18] | 0.003 |
| WBC countc | 3.14 [1.92–5.14] | <0.0001 | 1.21 [0.67–2.19] | 0.520 |
| Cytogenetic riskd | 1.79 [1.25–2.57] | 0.002 | – | – |
| TP53e | 2.85 [1.41–5.75] | 0.004 | – | – |
| RUNX1e | 2.08 [1.10–3.93] | 0.023 | – | – |
| DNMT3Ae | 1.74 [1.13–2.68] | 0.012 | 1.95 [1.11–3.44] | 0.020 |
| IDH1e | – | – | 0.60 [0.21–1.75] | 0.351 |
Notes:
a
Low vs high expression.
b
>60 vs ≤60 years.
c
≥30 vs <30 × 109/L.
d
Adverse vs intermediate vs favorable.
e
Mutated vs wild type.
Abbreviations: TCGA, The Cancer Genome Atlas; CN-AML, cytogenetically normal AML; WBC, white blood cells; CI, confidence interval.
Hazard Ratio > 1 or Hazard Ratio < 1 indicate a higher or lower risk. Only variables with a univariable P ≤ 0.20 were included in the multivariable models.