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. 2021 Jul 9;11:666143. doi: 10.3389/fcimb.2021.666143

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Copyright © 2021 Journo, Ahuja, Dias-Polak, Eran, Bergman and Shamay

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hyper-methylation in KS is prevalent in enhancer regions. (A) Heat map of the most differentially methylated CpG sites (raw β values) comparing control and KS samples. Hyper (red) and hypo (blue) methylation threshold was set as Δβ≥0.25 and Δβ≤-0.25 respectively with FDR ≤ 0.05. (B, C) Pie charts representing the percentage of hyper and hypo-methylated CpGs that are located within cellular promoters (orange) and enhancers (purple) for plaque (B) and nodule (C). The number of cellular enhancers and promoters identified in our analysis are presented below.