Table 4.

Loop sequences of 19 selected transporters.

Transporters	Flexible-Loop	Distal-Loop	Interface-Loop	Switch-Loop
AcrB-Ec	PAIVELGT	EKSSSSFLM	PSSFLPDEDQG	GFGFAGR
AcrB-Sa	PAIVELGT	EKSSSSFLM	PSSFLPDEDQG	GFGFAGR
AcrF-Sa	PAIVELGT	EKSSSSFLM	PSSFLPDEDQG	GFSFSGQ
AcrF-Ec	PAIVELGT	EKSSSSYLM	PSSFLPEEDQG	GFSFSGQ
MexB-Pa	PSVLELGN	TKAVKNFLM	PEAFVPAEDLG	GFNFAGR
AcrD-Ec	PAISGLGS	RKTGDTNIL	PTSFLPLEDRG	GSGPGGN
AcrD-Sa	PAISGLGS	RKTGDTNIL	PTSFLPQEDRG	GSGPGGN
MexY-Pa	PPLPDLGS	EKAADSIQL	PQAFLPEEDQG	GFSLYGD
MexD-Pa	PPINGLGN	EQTSAGFLL	PEAFVPAEDLG	GFSFSGQ
AdeB-Ab	PAIDELGT	EASSSGFLM	PTAFMPEEDQG	GWGFSGA
AdeJ-Ab	PAMPELGV	TKSGASFLQ	PSSFLPEEDQG	GFSFTGV
MtrD-Ng	PPILELGN	SKARSNFLM	PTSFLPTEDQG	GFSFSGS
MexQ-Pa	PPVPGLGT	QKTSPDILM	PPGFVPMQDKY	GLSVNGF
MexF-Pa	PPVPGLGT	DKASPDLTM	PTGFVPQQDKQ	GLSINGF
AdeG-Ab	PPVMGLGT	LKSSPTLTM	PGGFVPAQDKQ	GLSINGF
MexI-Pa	AALPGST–	SSGETTAVA	KRELAPTEDQA	TWIINGT
LpeB-Lp	PGVDDAG–	QRK–SNGLP	SHETAPKEDRG	RLTFIGD
AcrB-Hi	PEIDTGE–	SSG–GSGIM	SSELTPNEDKG	GMSIAGA
MexW-Pa	PSLPGTG–	EAADASALM	KKELAPEEDQG	AFQINGY

Bold underlined, fully conserved. A bar (–) indicates a gap in the sequence alignment.