Figure 2.
KaftrioTM effect on CFTR-dependent Cl-secretion. Isc response to FSK Forskolin (10 μM), IBMX (100 μM) (ΔIscF/I) after treatment for 24 h with DMSO (No-treated) or a combination of VX-445 (3 μM), VX-661 (3 μM) and VX-770 (100 nM) (Treated). ΔIscF/I recording experiments on brushed nasal epithelial cells from CF patients (two filters per patients, n = 3) with F508del/Unknown genotype and control subjects (two filters per subject, n = 6). CF NT: Cystic Fibrosis patients Non Treated (white circles), CF Treated (black circles), CTR NT: Control subjects Non Treated (white squares), CTR Treated (black squares). The p-values for statistically significant differences are indicated as * <0.031. In the Table 2 are presented the statistical analysis of the samples analyzed.