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. 2021 Jul 1;10(7):803. doi: 10.3390/antibiotics10070803

Table 1.

Antibacterial activity of diarylureas.

Microorganisms (MIC, µg/mL)
Gram-Positive Gram-Negative
Compd Structure S.a. 25923 S.a. 29213 S.a. 6538 S.a. 6538p E.f. 29212 P. a. 27853 K.p. 13883
2eA graphic file with name antibiotics-10-00803-i001.jpg nt 64 32 16 32 >256 >256
2eB graphic file with name antibiotics-10-00803-i002.jpg nt 64 128 A.N. 32 >256 A.N.
2bB graphic file with name antibiotics-10-00803-i003.jpg nt 16 128 A.N. 8 >256 A.N.
2cC graphic file with name antibiotics-10-00803-i004.jpg A.N. >512 A.N. >512 A.N. A.N. A.N.
2bC graphic file with name antibiotics-10-00803-i005.jpg 128 128 64 64 256 >512 >512
2bF graphic file with name antibiotics-10-00803-i006.jpg 32 32 8 8 32 >512 >512
2eE graphic file with name antibiotics-10-00803-i007.jpg 16 16 16 16 64 >512 >512
2eC graphic file with name antibiotics-10-00803-i008.jpg 16 16 8 8 32 >512 >512
2dC graphic file with name antibiotics-10-00803-i009.jpg 512 512 256 128 128 >512 >512
2bG a graphic file with name antibiotics-10-00803-i010.jpg 32 32 64 64 32 >512 >512
NRF b - 0.5–2 nt nt 2–8 1–4 nt
TCC 16 16 128 16 64 256 256

Antibacterial activity was assessed using the CLSI assay (2012) [39]. Abbreviations: S.a.: S. aureus; E.f.: E. faecalis; P.a.: P. aeruginosa; K.p.: K. pneumoniae. NRF: norfloxacin; TCC: triclocarban; nt: not tested; a bactericidal action; b Values according to CLSI (2012) [39].