Figure 3.

Changes in the FIS-40 domain scores during the intervention study. Each bar indicates the mean FIS-40 item scores ± SEM compared by a paired Student’s t-test, where appropriate, for intragroup analysis and by a Wilcoxon’s signed rank test for intergroup analysis. (A) Physical functioning domain; (B) Cognitive domain; (C) Psychological domain; (D) Total FIS-40 score. The significance threshold was set at * p < 0.05 and ** p < 0.01. No significant differences in any FIS-40 domain scores were observed between the intervention groups in the rest of study visits. Lower scores indicate an improvement in the fatigue perception among participants. Abbreviations: Mel-Zinc, Melatonin plus Zinc group; FIS-40, 40-item fatigue index scale.