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Pharmacokinetic parameters and PK/PD targets of tedizolid and linezolid used for Monte Carlo simulations. CL data are expressed as mean ± standard deviation.
| Antibiotic | Dosing Regimen |
CL (L/h) | Fu | PK/PD Target | References |
|---|---|---|---|---|---|
| Tedizolid | 200 mg q24h | 6.69 ± 2.07 | 0.10 | fAUC24/MIC ≥ 3 | [19,21,42] |
| Linezolid | 600 mg q12h | 4.80 ± 1.74 | 0.69 | fAUC24/MIC ≥ 80 | [19,20,43] |
CL: total body clearance; Fu: unbound fraction; fAUC24: area under the unbound concentration–time curve over a period of 24 h.
