Table 2.
The PD target of danofloxacin against G. parasuis.
| Time (h) | Cvivo | (AUIC)ex | E (logCFU/mL) | Calculated PD Target |
|---|---|---|---|---|
| 0 | 0.00 | 0.00 | 3.62 | E0 = 3.62 PDmax = 8.67 EC50 = 15.24 γ = 1.85 AUIC (E = 0) = 12.73 AUIC (E = −3) = 28.68 AUIC (E = −4) = 44.38 |
| 0.5 | 2.11 ± 0.37 | 25.34 ± 4.39 | −3.12 | |
| 1 | 3.13 ± 0.35 | 37.54 ± 4.21 | −5.05 | |
| 1.5 | 3.89 ± 0.11 | 46.70 ± 1.37 | −5.05 | |
| 2 | 3.51 ± 0.33 | 42.15 ± 3.96 | −5.05 | |
| 3 | 3.02 ± 0.21 | 36.28 ± 2.53 | −5.05 | |
| 4 | 2.23 ± 0.25 | 26.81 ± 2.95 | −3.59 | |
| 6 | 1.56 ± 0.45 | 18.72 ± 5.39 | −1.84 | |
| 8 | 1.02 ± 0.23 | 12.28 ± 2.75 | −1.07 | |
| 10 | 0.69 ± 0.19 | 8.31 ± 2.33 | 1.49 | |
| 12 | 0.38 ± 0.16 | 4.56 ± 1.90 | 3.24 | |
| 24 | 0.27 ± 0.03 | 3.24 ± 0.31 | 3.34 |
Cvivo is the concentration of danofloxacin in PELF; (AUIC)ex is selected PK-PD parameters; a represented the bacterial colonies lower than the limit of detection (10 CFU/mL).