Figure 2.

Three different CRISPR-Cas strategies to combat AMR. (A) Species-specific targeting kills both susceptible and resistant clones of the same species, leaving the rest of the microbial population unaltered. (B) Resistant clones-specific targeting kills only bacteria harboring genes for AMR, leaving susceptible clones and the rest of the population unaffected. (C) Resensitization turns resistant clones into susceptible ones by specifically targeting resistance genes, without an effect on the rest of the microbial population.