Table 1.

Classification of BL and spectrum of activity of BLIs [2,17,22,24,25,26,27,28,29].

β-Lactamases			Substrates					Spectrum of Activity of BLIs
Active Site	Ambler Class	Representative Enzymes
			Pen	Cep	ECep	Cbn	Mb	AVI	REL	VAB	DUR	ZID	NAC	TAN
Serine	A	PC1	✓					✓	✓	✓	✓
		TEM-1, TEM-2, SHV-1	✓	✓				✓	✓	✓	✓	✓	✓	✓
		CTX-M-15, GES-1, VEB-1	✓	✓	✓		✓	✓	✓	✓	✓	✓	✓	✓
		IRT, SHV-10, TEM-30	✓					✓	✓	✓	✓	✓	✓	✓
		CARB-1, PSE-1	✓					✓	✓	✓	✓
		KPC, SME-1, GES-2	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓	✓
	C	AmpC, P99, ACT-1, MIR-1		✓				✓	✓	✓	✓	✓	✓	✓
		GC1, CMY-37		✓						✓	✓	✓
	D	OXA-1, OXA-10	✓					+/−	+/−		✓	✓		✓
		OXA-11, OXA-15	✓		✓		✓	+/−	+/−		✓
		OXA-23, OXA48	✓			✓		✓	+/−		✓	+/−	✓	✓
MBL	B	IMP, VIM, NDM	✓	✓	✓	✓						✓	✓	✓
		CphA, Sfh-1				✓								✓

Abbreviations: BL, β-lactamase; MBL, metallo-β-lactamase; Pen, penicillins; Cep, cephalosporins; ECep, extended-spectrum cephalosporins; Cbn, carbapenems; Mb, monobactams. Symbols: ✓, substrate or inhibitor; +/−, variable activity.