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. 2021 Jun 24;10(7):1020. doi: 10.3390/antiox10071020

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Representation of melatonin effects on NLRP3 inflammasome activation. Melatonin shows ameliorative effects on NLRP3 inflammasome activation via interacting with certain signaling pathways. NLRP3: NLR family pyrin domain containing 3; ASC: apoptotic-associated speck-like protein containing a caspase recruitment domain; ROS: reactive oxygen species; TXNIP: thioredoxin-interacting protein; Nrf2: nuclear factor erythroid 2-related factor 2; Sirt-1: sirtuin 1, IL-1β: interleukin 1β; NF-κB: nuclear factor kappa B.