Figure 2.

Interplay of intracellular pathways leading to structural alteration and function in kidney and heart. Ang II—angiotensin II; RhoGEF—Rho guanosine exchange factor; ROCK –Rho kinase; NFκB—nuclear factor kappa B; PAI-1—plasminogen activator inhibitor 1; CXs—connexins; NOX—nicotinamide adenine dinucleotide phosphate oxidases; O₂^•−—superoxide; NO—nitric oxidie; TGFβ —transforming growth factor β; MAPK—mitogen activated protein kinase; ERK 1/2—extracellular regulated signal kinase. Image created with BioRender.com.