Figure 3.

Network of DR-associated mutations in the clade Haarlem (Lineage 4.3). Polymorphic loci are shown as nodes titled by the respective gene name and the polymorphic codon number following the colon. Mutations known to cause DR are depicted by an orange color. Nodes linked exclusively by outgoing edges (prerequisite mutations) are shown in green, and those linked exclusively by incoming edges (final and compensatory mutations) are shown in pink, while intermediate mutations are shown in blue. Arrows show relations between prerequisite and subordinate mutations. Major steps of DR evolution in the Haarlem clade are shown as sick red arrows, and the directions to the major compensatory mutation lldD2:3 are shown as sick black arrows.