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. 2021 Jun 29;10(7):1040. doi: 10.3390/antiox10071040

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Scheme 1 — Illustration of the developed workflow for validating SC derivatives as highly-accessible therapeutic agents for the delay of neurodegeneration in PD (Created with Biorender.com, accessed 1 June 2021). (1) The sugarcane is processed by a thermally controlled process to obtain juice, syrup, and NCS containing the bioactive compounds. (2) A preliminary characterization of biological response is conducted in vitro that included assays for antioxidant activity, phenolic content, and cytotoxicity. (3) Bioactive compounds were extracted by methanolic extraction and, subsequently, analytical HPLC-MS were carried out for identification and quantification. (4) The neuroprotective activity of SC derivatives was evaluated in vitro in a rotenone-induced model via mitochondrial membrane potential, apoptosis, and MAO-B activity.