Figure 1.

Interaction between phage Sb-1 and oxacillin against the MRSA clinical isolate SA19. (a) The mean bacterial density (OD₅₉₀) of three biological replicates over time is shown using the phage at an MOI of 0.1 and oxacillin at a concentration of 10 µg/mL in liquid medium. (b) The percentage of bacterial reduction based on the area under the curve (AUC) of the treated bacteria in relation to the AUC of the untreated bacteria, using phage MOIs ranging from 10 to 0.00001. The bars represent the mean reduction of each treatment for three biological replicates ± standard deviations. The stars indicate statistical support for an enhanced antibacterial effect of the dual approach in comparison with the effect of the phage alone or with the theoretical additive effect. ** p < 0.01. * p < 0.05.