Skip to main content
. Author manuscript; available in PMC: 2022 Jul 22.
Published in final edited form as: J Med Chem. 2021 Jul 12;64(14):9960–9988. doi: 10.1021/acs.jmedchem.1c00184

Figure 10. HDAC6 inhibitors show a concentration dependent inhibitory effect on bronchosphere formation.

Figure 10.

IC50 value were determined from bronchosphere counts and bronchosphere cell proliferation by GraphPad Prism 9 (mean ± SEM, n = 3). The mean value is determined from the IC50 value of the organoid counts and the MTT assay. Calculated IC50 values represents the concentration of the best HDAC6 inhibitor compounds 6a, 6d, 6h and 6l at which they exert their half of maximal inhibitory effect on bronchosphere formation in 3D organoid assay.