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. Author manuscript; available in PMC: 2022 Jul 22.
Published in final edited form as: J Med Chem. 2021 Jul 12;64(14):9960–9988. doi: 10.1021/acs.jmedchem.1c00184

Figure 11. HDAC6 inhibition attenuates TGF-β1-dependent pro-fibrotic gene expression in ex vivo cultured human lung parenchyma.

Figure 11.

A) α-SMA actin mRNA expression is upregulated by TGF-β1 and inhibited by 6h 4.1 μM (n = 6). **p < 0.01, *p < 0.05, paired t test. B) Collagen type I mRNA expression is upregulated by TGF-β1 and inhibited by 4.1 μM (n=6) **p < 0.01, *p < 0.05, paired t test. C) Collagen type III mRNA expression is upregulated by TGF-β1 and inhibited by 4.1 μM (n=6). *p < 0.05, paired t test. D) Fibronectin mRNA expression is upregulated by TGF-β1 and inhibited by 4.1 μM (n = 6). *p < 0.05, paired t test. E) HDAC6 mRNA is expressed in human lung parenchyma (n=3). F) HDAC6 mRNA expression is inhibited by 4.1 μM (n=3), *p < 0.05, paired t test. NS = non stimulated.