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. Author manuscript; available in PMC: 2022 Jul 22.
Published in final edited form as: J Med Chem. 2021 Jul 12;64(14):9960–9988. doi: 10.1021/acs.jmedchem.1c00184

Figure 8. The newly generated HDAC6 inhibitors showed a concentration-dependent inhibitory effect on bronchosphere formation in 3D organoid cultures derived from IPF ABC.

Figure 8.

(A-D) ABC of IPF patients (n = 3) in 3D organoid cultures were stimulated for 14 days with the newly developed HDAC6 inhibitors 6a (A), 6d (B), 6h (C), 6l (D) in a concentration range from 0.1 to 50 nM. Bright field microscopy mosaic images of one representative experiment were taken with an Observer.Z1 Zeiss microscope and exemplary registrations are depicted.