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. Author manuscript; available in PMC: 2022 Jul 22.
Published in final edited form as: J Med Chem. 2021 Jul 12;64(14):9960–9988. doi: 10.1021/acs.jmedchem.1c00184

Table 2.

Inhibitory activity of compounds 6d,h,l, as IC50 (μM), against the hHDAC8 enzyme.a

Compound 6d 6h 6l TubA28
IC50 (μM)a 3.49 ± 1.54 2.17 ± 0.70 4.64 ± 1.28 0.695
a

Concentration range of all compounds (40 nM-50 μM) was determined using the reference compound TubA and the results are expressed with standard deviations.