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. Author manuscript; available in PMC: 2022 Jul 22.
Published in final edited form as: J Med Chem. 2021 Jul 12;64(14):9960–9988. doi: 10.1021/acs.jmedchem.1c00184

Table 4.

Kinetic parameters and metabolic stability of compounds 6d and 6h.

Compound k (min−1) t1/2 (min) CLint (μL/min/mg prot)
6d 0.01297 51.68 27.43
6h 0.01357 53.47 25.46
SAHA44 60