Table 5.
Viability of mouse fibroblasts NIH3T3 after incubation with different concentrations of 6h and reference HDAC inhibitor SAHA (%).a
| [μM] | 1 | 2 | 2.5 | 5 | 7.5 | 10 | 15 | 20 | 25 | 50 | 75 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 6h | 98 ± 6 | 94 ± 9 | *87 ± 5 | *71 ± 9 | *53 ± 10 | ||||||
| SAHA | *83±6 | *62±5 | *49±3 | *31±5 | *22±3 | *17±6 | *7±6 |
a
Cell viability was measured by the Neutral Red Uptake (NRU) test and data normalized as % control. Data are expressed as mean ± s.d. of three experiments repeated in six replicates.
*
Values are statistically different versus control, p ≤ 0.05.