. Author manuscript; available in PMC: 2022 Jul 22.

Published in final edited form as: J Med Chem. 2021 Jul 12;64(14):9960–9988. doi: 10.1021/acs.jmedchem.1c00184

Table 6.

Effects of 6h on HR, RR, PQ, QRS, QT, and QTc in Langendorff perfused rat hearts

6h (μM)	HR (BPM)	RR (ms)	PQ (ms)	QRS (ms)	QT (ms)	QTc (ms)
none	235.7±8.3	257.2±8.1	43.6±2.5	15.2±0.2	76.2±2.9	150.5±5.5
0.01	235.4±9.2	255.9±9.3	44.1±2.6	15.6±0.5	78.1±3.2	154.6±5.8
0.1	238.1±10.5	253.7±10.0	44.6±3.2	15.4±0.4	78.0±3.3	155.1±6.6
1	235.4±12.0	257.7±11.2	44.5±3.0	15.8±0.4	76.4±3.1	150.8±6.1
10	207.9±17.1^**	294.1±20.9^**	50.4±2.2^**	18.0±0.5^**	78.3±3.4	145.3±5.7

Each value represents mean ± SEM (n = 5).

^**

P< 0.01, repeated measures ANOVA and Dunnett’s post-test). HR, frequency; RR, cycle length; PQ, atrioventricular conduction time; QRS, intraventricular conduction time; QT, duration of ventricular depolarization and repolarization, i.e., the action potential duration; QTc, corrected QT.