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. 2021 Jul 20;10(7):1153. doi: 10.3390/antiox10071153

Figure 1.

Figure 1

βHB upregulates Trx1. (A) Dosage effect of βHB on Trx1 expression. Cardiomyocytes were treated with the indicated concentrations of βHB for 16 h. n = 6–8 (Trx1) and 5–7 (Prdx1). (B) Time-dependent effect of 1 mM βHB on Trx1 in cardiomyocytes. n = 5–7. (C) βHB upregulates Trx1 in cardiac fibroblasts. Cardiac fibroblasts were treated with 3 mM βHB for 16 h. n = 6. (D) Ketogenic diet consumption upregulates Trx1 in the heart in vivo. n = 4. Western blot analyses with indicated antibodies were performed. * p < 0.05 (A–D).