Table 2.
The top 12 cellular component GO terms enriched of DEGs in T21-iPSCs from Webgestalt analysis.
| Gene Set | Description | Size | Expected | Observed | Ratio | p Value | Adjusted p Value |
|---|---|---|---|---|---|---|---|
| GO:0015630 | microtubule cytoskeleton | 1164 | 103.88 | 186 | 1.79 | 7.7716 × 10−16 | 9.1316 × 10−13 |
| GO:0005694 | chromosome | 1014 | 90.49 | 165 | 1.82 | 7.7716 × 10−15 | 4.5658 × 10−12 |
| GO:0031984 | organelle subcompartment | 1661 | 148.23 | 237 | 1.61 | 1.9984 × 10−14 | 7.8271 × 10−12 |
| GO:0044427 | chromosomal part | 886 | 79.07 | 146 | 1.85 | 1.1569 × 10−13 | 3.3983 × 10−11 |
| GO:1902494 | catalytic complex | 1346 | 120.12 | 196 | 1.63 | 1.3223 × 10−12 | 3.0482 × 10−10 |
| GO:1990234 | transferase complex | 766 | 68.36 | 128 | 1.87 | 1.5565 × 10−12 | 3.0482 × 10−10 |
| GO:0005794 | Golgi apparatus | 1516 | 135.29 | 214 | 1.58 | 2.3663 × 10−12 | 3.9721 × 10−10 |
| GO:0031967 | organelle envelope | 1156 | 103.16 | 172 | 1.67 | 6.2294 × 10−12 | 8.1328 × 10−10 |
| GO:0031975 | envelope | 1156 | 103.16 | 172 | 1.67 | 6.2294 × 10−12 | 8.1328 × 10−10 |
| GO:0044430 | cytoskeletal part | 1620 | 144.57 | 221 | 1.53 | 2.8619 × 10−11 | 3.3627 × 10−9 |
| GO:0005739 | mitochondrion | 1555 | 138.77 | 213 | 1.53 | 4.7783 × 10−11 | 5.1041 × 10−9 |
| GO:0005730 | nucleolus | 939 | 83.80 | 143 | 1.71 | 8.5312 × 10−11 | 8.3535 × 10−9 |
The GO term “mitochondrion” was very significantly enriched (FDR = 5.1041 × 10−9) with 213 genes observed in the list instead of the 139 genes expected by chance. The bold is to highlight the mitochondrion category.