Figure 4.

SP treatment prevents alteration of cytokine profile in cardiac microendothelial cells after high glucose treatment. (A) Experimental scheme for glucose and SP treatment. (B) Angiogenesis-related cytokine profile was analyzed via cytokine arrays. The relative expression was quantified using image J. Values of p < 0.05 were considered significant (* p < 0.05, ** p < 0.01, *** p < 0.001). The data are expressed as the mean ± standard deviation of three independent experiments. SP, substance-P; NRG-B1, neuregulin beta 1; EG-VEGF, endocrine gland-derived vascular endothelial growth factor; FGF, fibroblast growth factor; IL-1b, interleukin 1 beta; PDGF, platelet-derived growth factor.