Table 3.
MAP, lipid profile, hormone concentrations, inflammatory parameters and miRNA levels in the serum of young rats, old rats and old rats treated with the oil mixture and the OLE.
| Young | Old | Old + Oil Mixture + OLE | |
|---|---|---|---|
| MAP (mmHg) | 123.6 ± 3.0 | 140.1 ± 6.1 * | 114.8 ± 1.8 # |
| Glycemia (mg/dL) | 90.7 ± 3.8 | 72.4 ± 11.1 | 55.0 ± 7.9 *** |
| Total Lipids (mg/dL) | 853.1 ± 63.9 | 1051 ± 37.4 * | 793.3 ± 56.7 ## |
| Triglycerides (mg/dL) | 97.6 ± 13.5 | 158.5 ± 36.4 * | 63.5 ± 15.4 # |
| Total Cholesterol (mg/dL) | 135.1 ± 15.3 | 199.3 ± 13.9 * | 114.3 ± 13.6 ## |
| LDL-cholesterol (mg/dL) | 28.8 ± 2.7 | 47.8 ± 2.6 ** | 17.82 ± 3.0 *### |
| HDL-cholesterol (mg/dL) | 15.7 ± 0.6 | 13.4 ± 2.2 | 13.0 ± 1.5 * |
| Insulin (ng/mL) | 17.7 ± 5.2 | 81.3 ± 32.2 ** | 19.9 ± 3.7 *# |
| HOMA-Index | 1.75 ± 0.3 | 13.1 ± 5.4 * | 2.59 ± 0.7 # |
| Leptin (ng/mL) | 11.82 ± 1.4 | 30.2 ± 5.9 ** | 35.8 ± 7.6 ** |
| Adiponectin (mg/dL) | 67.1 ± 6.7 | 108.9 ± 4.3 *** | 145.6 ± 7.5 ***## |
| Interleukin-6 (pg/mL) | 135.6 ± 7.1 | 188.7 ± 24.1 * | 130.1 ± 34.1 # |
| TNFα (pg/mL) | 0.1 ± 0.1 | 1.8 ± 0.9 * | 0.3 ± 0.2 # |
| miRNA-21/U6 (%) | 100.0 ± 39.6 | 447.3 ± 151.3 * | 155.6 ± 48.7 # |
| miRNA-34a/U6 (%) | 100.0 ± 18.7 | 325.4 ± 96.3 * | 304.8 ± 140.2 |
| miRNA-146a/U6 (%) | 100.0 ± 16.6 | 184.3 ± 43.8 * | 51.4 ± 16.0 ## |
| miRNA-204/U6 (%) | 100.0 ± 33.8 | 105.2 ± 38.3 | 101.7 ± 34.5 |
Data are represented as mean value ± SEM; n = 8–11 samples/group. * p < 0.05 vs. Young; ** p < 0.01 vs. Young; *** p < 0.001 vs. Young; # p < 0.05 vs. Old; ## p < 0.01 vs. Old; ### p < 0.001 vs. Old. MAP = Medial Arterial Pressure.