Table 1.

Drugs proven to decrease both the oxidative stress and cognitive dysfunction induced by the administration of chemotherapeutic drugs in animal models.

Antioxidant Compound	Drug-Induced Cognitive Impairment and Oxidative Stress	Behavioural Test Used to Assess Cognitive Function
N-acetylcysteine [88]		Recognition memory task
	Cisplatin	Fear conditioning learning
		Object discrimination
N-acetylcysteine [54] Doxorubicin Recognition memory task Cyclophosphamide
Gamma-glutamyl cysteine ethyl ester [89]	Adriamycin	Recognition memory task
Polydatin [56]		Morris water-maze task
	Doxorubicin	Step-down avoidance task
Caffeic acid phenethyl ester [57]	Doxorubicin	Passive avoidance test
		Morris water-maze task
MESNA [53]	Doxorubicin	Recognition memory task

MESNA, 2-mercaptoethane sulfonate sodium.