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. 2021 Jul 9;9:619396. doi: 10.3389/fcell.2021.619396

FIGURE 2.

FIGURE 2

Association between the ER stress-related signature and clinicopathologic features in TCGA and CGGA datasets. (A–E) The association between risk score and WHO grade (A), IDH mutation status (B), MGMT promoter methylation (C), 1p/19q co-deletion status (D) and histopathologic classification (E) of glioma patients. (F) The distribution of risk score in the different location of GBM in IVY GBM dataset. (G,H) In glioma samples, the Mesenchymal subtype had the highest risk score among four molecular subtypes. ROC curves predicted ER stress activation as a biomarker of Mesenchymal subtype glioma. (I,J) In GBM samples, the Mesenchymal subtype had the highest risk score among four molecular subtypes. ROC curves predicted ER stress activation as a biomarker of Mesenchymal subtype glioma. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns: no statistically significant.