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. Author manuscript; available in PMC: 2021 Jul 23.

Published in final edited form as: Wiley Interdiscip Rev Data Min Knowl Discov. 2011 Jan 10;1(1):88–95. doi: 10.1002/widm.13

FIGURE 1 | — The optimal structure (OS) and corresponding optimal restrained structure (ORS) computed from Caenorhabditis elegans let-7 precursor sequence (a) and its randomly shuffled sequence (b). The computed lowest free energies of OS and ORS for the natural functional RNA are −38.5 (E) and −13.8 (E_f) kcal/mol, and from the randomly shuffled sequence are −15.0 (E) and 13.9 (E_f) kcal/mol, respectively. E_diff values are 24.7 kcal/mol for the let-7 precursor and 1.1 kcal/mol for its randomly shuffled sequence. It is quite obvious that the greater E_diff of the folded let-7 wild-type sequence indicates a significantly more well-ordered OS.¹⁷

FIGURE 1 | — The optimal structure (OS) and corresponding optimal restrained structure (ORS) computed from Caenorhabditis elegans let-7 precursor sequence (a) and its randomly shuffled sequence (b). The computed lowest free energies of OS and ORS for the natural functional RNA are −38.5 (E) and −13.8 (E_f) kcal/mol, and from the randomly shuffled sequence are −15.0 (E) and 13.9 (E_f) kcal/mol, respectively. E_diff values are 24.7 kcal/mol for the let-7 precursor and 1.1 kcal/mol for its randomly shuffled sequence. It is quite obvious that the greater E_diff of the folded let-7 wild-type sequence indicates a significantly more well-ordered OS.¹⁷