Figure 1. Application of RNA, RNA/DNA and DNA/RNA for RNAi activation.

(a) Schematic representation of the assemblies leading to the formation of RNA nanocubes and nanorings functionalized with DS RNAs. (b) Schematic representation of the re-association of the RNA/DNA nanocubes and nanorings initiated by toehold interaction and further release of the siRNAs from the RNA nanorings. (c) Re-association of DNA/RNA nanocubes and hybrids trigger the release of DS RNA further diced into the siRNAs.