Table 2.
Therapy (BPC 157 10 µg/kg, 10 ng/kg) started after monocrotaline (80 mg/kg sc) application on day 14. Assessment on day 14 (before therapy initiation) and on day 30 (end of the therapy); means ± SE. Therapeutic regimens. A. Medication: BPC 157 one time daily, intraperitoneally; first application day 14 after monocrotaline, last 24 h before sacrifice. B. Medication: BPC 157 (0.16 µg/mL/rat/day or 0.16 ng/mL/rat/day) continuously in drinking water from day 14 until sacrifice.
| Monocrotaline (80 mg/kg sc, Day 0) Rats | |||||||
|---|---|---|---|---|---|---|---|
| Assessed Parameters |
Day 14 (before Therapy Initiation) § p < 0.05, at Least, vs. day 14 |
Day 30 (at the End of Therapy Protocol) | |||||
| After Monocrotaline Application Therapy Started at Day 14 | |||||||
| A. Medication: One Time Daily, Intraperitoneally * p ˂ 0.05, at Least, vs. Control |
B. Medication: BPC 157 Continuously in Drinking Water Until Sacrifice # p ˂ 0.05, at Least, vs. Control |
||||||
| 0.9% NaCl 5 mL/kg |
BPC 157 10 µg/kg | BPC 157 10 ng/kg | Drinking Water 12 mL/rat /day |
BPC 157 10 µg/kg water |
BPC 157 10 ng/kg | ||
| BW end (g) | 201.33 ± 6.4 | 207.6 ± 5.19 | 233.17 ± 9.24 *§ | 232.17 ± 5.15 *§ | 205.75 ± 3.20 | 240.17 ± 7.41 #§ | 232.33 ± 4.45 #§ |
| heart (g) | 0.77 ± 0.05 | 1.02 ± 0.04 § | 0.85 ± 0.04 | 0.87 ± 0.03 | 1.04 ± 0.02 § | 0.90 ± 0.05 | 0.93 ± 0.03 |
| RV (g) | 0.15 ± 0.01 | 0.26 ± 0.02 § | 0.15 ± 0.01 *§ | 0.18 ± 0.01 *§ | 0.29 ± 0.01 § | 0.16 ± 0.01 #§ | 0.19 ± 0.01 #§ |
| LV + IVS (g) | 0.41 ± 0.03 | 0.49 ± 0.01 | 0.52 ± 0.04 | 0.5 ± 0.02 | 0.5 ± 0.02 | 0.54 ± 0.03 | 0.55 ± 0.02 |
| liver (g) | 6.39 ± 0.44 | 12.85 ± 0.31 § | 7.47 ± 0.58 *§ | 9.06 ± 0.33 *§ | 13.19 ± 0.22 § | 8.19 ± 0.50 #§ | 8.47 ± 0.62 #§ |
| RV/ (LV + IVS) |
0.37 ± 0.02 | 0.53 ± 0.03 § | 0.29 ± 0.01 *§ | 0.36 ± 0.02 *§ | 0.55 ± 0.02 § | 0.29 ± 0.01 #§ | 0.34 ± 0.01 #§ |
| RV/BW (mg/g) |
0.75 ± 0.04 | 1.27 ± 0.07 § | 0.64 ± 0.01 *§ | 0.77 ± 0.01 *§ | 1.39 ± 0.07 § | 0.66 ± 0.01 #§ | 0.80 ± 0.01 #§ |
| liver/BW (mg/g) |
31.74 ± 1.83 | 62.07 ± 2.35 § | 31.86 ± 1.54 *§ | 39.07 ± 1.44 *§ | 64.13 ± 0.99 § | 34.05 ± 1.59 #§ | 36.43 ± 2.47 #§ |
| media area % |
35.79 ± 0.79 | 41.92 ± 0.93 | 23.33 ± 1.02 *§ | 30.15 ± 0.86 | 43.51 ± 1.40 | 22.58 ± 0.86 #§ | 28.50 ± 0.91 #§ |
| heart rate | 366.00 ± 2.73 | 316.02 ± 6.81 § | 387.83 ± 4.59 *§ | 378.83 ± 6.74 *§ | 319.20 ± 7.14 § | 375.50 ± 4.19 #§ | 379.17 ± 4.73 #§ |
| respiration rate |
114.67 ± 3.00 | 139 ± 8.59 § | 98.67 ± 1.98 *§ | 100.7 ± 1.61 *§ | 131 ± 7.42 § | 112.67 ± 2.81 #§ | 111.33 ± 1.91 #§ |
| QT interval | 61 ± 5.94 | 80 ± 3.82 § | 48 ± 3.10 *§ | 52.7 ± 3.01 *§ | 89 ± 3.65 § | 45.5 ± 2.75 #§ | 56.33 ± 0.76 #§ |