Figure 3.

(A) UpSet plot of distinct intersections of transcripts up-regulated at the ‘early’ (i.e., 2 DSS cycles) and ‘late’ (i.e., 4 DSS cycles) stages of AOM/DSS-induced carcinogenesis in the disease-resistant proximal and disease-sensitive distal part of the colon. The ‘susceptibility-associated gene signature’ (SAS), comprising 165 transcripts, was used for gene ontology and pathway enrichment. (B) KEGG and Reactome pathway enrichment of SAS transcripts. (C) Analysis of putative protein–protein interactions through the STRING option of FLAME. A cluster of interacting components of interferon beta (IFNβ) response and of T cell-associated immunity, including Th1/Th2 differentiation, Th17 differentiation, and cytokine–cytokine receptor interaction, each represented by a different color, is shown.