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. 2021 Jul 17;9(7):833. doi: 10.3390/biomedicines9070833

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Schematic representation of PITRM1 function and interaction. Mitochondrial Precursor proteins are imported from cytosol to the matrix through the Translocase of the Outer Membrane (TOM) and Translocase of the Inner Membrane (TIM) complexes. Dysfunctional activity of PITRM1 results in the accumulation of Amyloid beta (Aβ), of Mitochondrial Targeting Sequences (MTS) and of octapeptides that trigger feedback inhibition of Mitochondrial Processing Peptidase (MPP) and Mitochondrial Intermediate Peptidase (MIP), leading to the accumulation and aggregation of unprocessed precursor. Figure 1 was modified from SMART (Servier Medical Art), licensed under a Creative Common Attribution 3.0 Generic License. http://smart.servier.com/.