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Graphical abstract. Genotype load modulates amyloid burden and anxiety-like patterns in male 3xTg-AD survivors despite similar neuro-immunoendocrine and cognitive impairments. Experimental design and main findings. White square: NTg mice, yellow square: heterozygous 3xTg-AD mice, blue square: homozygous 3xTg-AD mice; Green square: 3xTg-AD mice (both 3xTg-AD genotypes, since no genotype-load differences were found).
