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. 2021 Jun 23;9(7):715. doi: 10.3390/biomedicines9070715

Figure 2.

Figure 2

Survival, HPA axis endocrine status and physical health. (A) Survival; (B) Corticosterone levels; (C) Body weight and (D) spleen weight in 19-month-old mice. Results are expressed as the mean ± SEM. Male NTg, n = 8 (White circles for individual values; white bar, mean value); male 3xTg-AD n = 9 (Yellow circles, individual values of heterozygous 3xTg-AD +/− mice, n = 5; Blue circles, individual values for homozygous 3xTg-AD +/+ mice, n = 4; Green bar, mean value of both 3xTg-AD genotypes, since no genotype-load differences were found). Statistics: two-tailed unpaired Student’s t-test (above the line) for Genotype differences (G): * p < 0.05; one-way analysis of variance (ANOVA) for comparisons between all the groups of mice followed by Bonferroni’s post-hoc test. * p < 0.05 vs. homozygous 3xTg-AD-group; # p < 0.05 vs. heterozygous 3xTg-AD-group.