Figure 5.

PLA2G7 silencing favored cancer progression by an activation of viability, proliferation, and migration. MTT results show that after 36 h siRNA (sequence S1 and S2) knockdown of PLA2G7, the viability of UWB1.289 increased significantly ((A); p < 0.001). DNA incorporation of BrdU was also significantly higher in the PLA2G7 downregulated group, indicating an increasing proliferation rate (B). The wound healing assay proved that the migration ability of PLA2G7-downregulated UWB1.289 cells was significantly activated compared to the control group ((C); p < 0.05). Significant results are indicated by asterisks (*: p ≤ 0.05) and double asterisks (**: p ≤ 0.001).