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. 2021 Jul 5;12:681277. doi: 10.3389/fgene.2021.681277

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Copyright © 2021 Wu, Wang, Zhu, Fu, Li, Wu and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction and validation of the eight-immune-related-lncRNA prognostic signature. (A) Screening and construction of an eight-immune-related-lncRNA prognostic signature by multivariate COX regression analysis. Forest plot shows hazard ratio (HR) and p-value of each lncRNA in the model. ** represents p < 0.01, *** represents p < 0.001. (B) Survival curves obtained by Kaplan–Meier survival analysis in high-risk and low-risk groups divided by the median risk score. (C) ROC curves and corresponding AUCs of 3-year survival and 5-year survival predicted by the prognostic model. (D) Distribution diagram of risk score of LUAD patients in TCGA-LUAD. The horizontal dotted line indicates the median risk score of all patients. (E) Distribution diagram of survival status of LUAD patients. Patient’s risk score is presented from low to high by left to right. The vertical dotted line represents the patients with a median risk score. Green dots represent survival and red dots represent death. (F) Heatmap of the expression of eight immune-related lncRNAs in cancer tissue of LUAD patients in high- and low-risk groups.