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. 2021 Jul 9;9(7):800. doi: 10.3390/biomedicines9070800

Figure 2.

Figure 2

Schematic representations of basal and bolus insulin secretory patterns (A) and secretion regulation (B). (A) The red line conceptually models glucose bolus mediated insulin secretory response pattern (Kraft I) [36], and the blue line conceptually models basal insulin pulsatile secretory pattern, in metabolically healthy individuals [34]. (B) Schematic representation of the regulatory cycles of basal and bolus insulin secretion in metabolically healthy, habitually fasted individuals. Beta-hydroxybutyrate (BHB), blood glucose (BG), glucagon-like peptide-1 (GLP-1), osteocalcin (OCN).