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. 2021 Jul 8;9(7):795. doi: 10.3390/biomedicines9070795

Figure 2.

Figure 2

Screening of menin-ASO inhibiting menin’s expression in TNBC. (a) Screening of menin-targeting ASOs. Hs 578T cells were treated with 100 nM of different menin-ASOs or control-ASO (SCR). Three days after the second transfection, proteins were extracted and analyzed by Western blot. ASO21 exhibits high potency of menin inhibition. (b) ASO21 inhibits menin’s expression in dose-dependent manner. Hs 578T cells were treated with ASO21 or control-ASO (SCR) at different concentrations: 200 nM, 300 nM and 400 nM. Three days after the second transfection, proteins were extracted and analyzed by Western blot.