(pS129) α-syn	phospho-Ser129 α-synuclein
5-HT	serotonin
6-OHDA	6-hydroxydopamine
ADE	anterior deirids neurons
AM	anteromedial
ANAD	atypical neuroaxonal dystrophy
AR EOPD	autosomal recessive early-onset Parkinson’s Disease
AR	autosomal-recessive
ARJP	autosomal recessive Juvenile Parkinsonism
ARPD	autosomal recessive Parkinson’s disease
ATP	adenosine triphosphate
BAC	bacterial artificial chromosome
BMP	lysosomal lipid Bis(monoacylglycero)phosphate
CAN	canal-associated neurons
CATD	cathepsin D
CEP	chepalic sensilla neurons
ChAc	chorea-acanthocytosis syndrome
CME	clathrin-mediated endocytosis
CNS	central nervous system
DA	dopamine
DAT	dopamine transporter
DCCD	dicyclohexylcarbodiimide
DHA	docosahexaenoic acid
DKO	double-KO
DL	dorsolateral
DM	dorsomedial
DOPAC	3,4-dihydroxyphenylacetic acid
Dpf	days postfertilization
DRP1	dynamin related protein-1
ENU	N-ethyl-N-nitrosourea
ETC	electron transport chain
FBP	F-box-containing protein
FBXO7	F-box protein 7
FCCP	carbonyl cyanide-p-trifluoromethoxyphenylhydrazone
GAK	cyclin G-associated kinase protein
GFAP	glia fibrillary acidic protein
GFP	green fluorescent protein
GSK-3β	glycogen synthase kinase 3 β
GWAS	genome-wide association study
H2O2	hydrogen peroxide
HAD	haloacid dehalogenase domain
HIF	hypoxia-inducible factor
Hpf	hours post-fertilization
HPLC	high performance liquid chromatography
HVA	homovanillic acid
IMS	mitochondrial intermembrane space
INAD	infantile neuroaxonal dystrophy
KD	knock-down
KI	knock-in
KO	knock-out
LAMP	lysosome-associated membrane glycoprotein
LC	locus coeruleus
LC-MS/MS	liquid-chromatography tandem mass spectrometry
LGR	L-glutathione reduced
LTD	long-term depression
LTP	long-term potentiation
MAO	monoamine oxidase
M-CATD	mature form of pH dependent lysosomal enzyme aspartyl protease ASP-3/CATD
MEFs	mouse embryonic fibroblasts
MFN2	mitofusin-2
Mn	manganese
MO	morpholino
MPP	mitochondrial processing peptidase
MPP+	1-methyl-4-phenylpyridinium
MPTP	1-methyl-4-phenyl-1,2,3,6-tetrapyridine
mPTP	mitochondrial permeability transition pore
mtDNA	mitochondrial DNA
MTS	mitochondrial targeting sequence
NAC	N-acetyl cysteine
NBIA	neurodegeneration with brain iron accumulation
NEO	neomycin
NEX	neuronal helix-loop-helix protein-1
OCR	oxygen consumption rate
P	postnatal day
PAG	periaqueductal gray
PARL	presenilin-associated rhomboid-like protease
P-CATD	premature form of pH dependent lysosomal enzyme aspartyl protease ASP-3/CATD
PD	Parkinson’s disease
PDE	posterior deirids neurons
PI	phosphatidylinositol
PINK1	(PTEN)-induced kinase 1
PNS	peripheral nervous system
PPM1/2	paired posterior medial 1 and 2 DA neuron clusters
PPM3	paired posterior medial 3 DA neuron cluster
PPS	Parkinsonian-pyramidal syndrome
rAAV2/8	recombinant type 2 adeno-associated viral vector pseudotyped with type 8 capsid
RNAi	RNA interference
RONS	reactive oxygen and nitrogen species
ROS	reactive oxygen species
SNc	substantia nigra pars compacta
β-PEA	β-phenylenthylamine
TGF-β	transforming growth factor-β
TH	tyrosine hydroxylase
TILLING	targeting induced local lesions in genomes
TIM23	translocase of the inner mitochondrial membrane
TMD	transmembrane domain
TOM	translocase of the outer mitochondrial membrane
TOM20	mitochondrial outer membrane protein
TUNEL	terminal deoxynucleotidyl transferase dUTP nick end labeling
USVs	ultrasound vocalizations
UVC	ultraviolet C
VEGF	vascular endothelial growth factor
VMAT2	vesicular monoamine transporter type-2
VPS	vacuolar protein sorting
WES	whole-exome sequencing
WT	wild type
ZFN	zinc finger nuclease
α-syn	α-synuclein