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. 2021 Jul 1;9(7):768. doi: 10.3390/biomedicines9070768

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The vicious circle of hyperinflammation. Circulating cytokines can induce vasodilatation leading to arteriovenous shunting in the microcirculation and eventually vasoplegic shock. Hypoperfused tissues may further amplify the effects of cytokine storm byconcomittantly triggering an immune response, potentially leading to ischemia–reperfusion injury. Hemoadsorption can potentially attenuate this vicious circle and protect the tissues from this onslaught by removing circulating cytokines and those released after tissue injury.