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. 2021 Jun 28;9(7):744. doi: 10.3390/biomedicines9070744

Figure 3.

Figure 3

Rat brain swelling presentation at 15 min ligation time in rats with superior sagittal sinus ligation. Rats received saline (C) or BPC 157 (B) and indicated with small white C and small white B close to the corresponding presentation. Swollen brain before medication (a,b,e–h), and after medication, given earlier at 1 min ligation-time (right, (C,D)). Therapy applied at 15 min ligation-time (A,B,E1,E2,F1,F2,G,H), presented the effect of medication at 5 min therapy-time (medication was given intraperitoneally (A,B) (upper, left, saline (small (C)), BPC 157 (small (B)), intragastrically (G,H) (upper, middle, saline (small (C)), BPC 157 (small (B)). Local application at the swollen brain. Swollen brain before medication (e,f). For medication given locally at the swollen brain (arrows), 30 s therapy-time (brain under solution, small C (control, saline), small B (BPC 157 solution)) and 45 s therapy-time (immediately upon solution resorption, small C (control, saline), small B (BPC 157 solution)) (low, (E1,E2) (saline), (F1,F2) (BPC 157)). Aggravation of the swelling, saline (intraperitoneally) (A), intragastrically (G); saline (topically) (E1) (30 s therapy-time), (E2) immediately upon solution resorption (45 s therapy-time). Attenuated swelling, BPC 157 (intraperitoneally (B); intragastrically (H) (at 5 min therapy-time); BPC 157 (topically) (F1) (30 s therapy-time), (F2) immediately upon solution resorption (45 s therapy-time). (C,D). Characteristic gross brain presentation with medication saline (C) or BPC 157 (D) given intraperitoneally at 1 min ligation time.