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. 2021 Jun 28;9(7):744. doi: 10.3390/biomedicines9070744

Figure 5.

Figure 5

Blood pressure of the rats with ligated superior sagittal sinus in the superior sagittal sinus (SSS), portal vein (PV), abdominal aorta (AA) and inferior caval vein (ICV), at the end of the 5 min assessment following medication (BPC 157 10 µg/kg, 10 ng/kg; saline 5 mL/kg) given intraperitoneally. Early medication at 1 min ligation time, blood pressure assessment before euthanized at 15 min (a), 24 h (b) and 48 h (c) ligation time. Delayed medication at 15 min (d), 24 h (e) and 48 h (f) ligation time. (g–i) For verification of the effect of venography, assessment at 5 min upon the additional 1 mL of saline application in the superior sagittal sinus (SSS), right external jugular vein (REJV) or inferior caval vein (ICV), inducing venous hypertension additionally originated within the cranium, inside the sinus lumen, neck or abdomen, at 15 min, and subsequent immediate ip application of saline or BPC 157. Similar effects were obtained with BPC 157 intragastric or local application at the swollen brain (data not specifically shown). Means ± SD, * p ˂ 0.05, at least vs. control; # p ˂ 0.05, at least vs. regular saline-control in non-venography studies.