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. 2021 Jun 28;9(7):744. doi: 10.3390/biomedicines9070744

Figure 11.

Figure 11

Neuropathologic changes in cerebral cortex areas (HE staining). Increased edema and congestion in control group (a–d) unlike BPC 157 rats (e–h). Application at ligation-time 15 min. (a) Control (1 min upon saline administration), a scant karyopyknosis in cerebral cortex, ligation-time 16 min; (b) Control (5 min upon saline administration), larger number of karyopyknotic neurons (arrows), ligation-time 20 min; (c) Control 24 h ligation-time (saline administration at 1 min ligation-time), complete infarction (rectangular marked area); (d) Control 48 h, ligation-time (saline administration at 1 min ligation-time, marked karyopyknosis (arrows)). BPC 157 rats exhibit a few karyopyknotic neurons (arrows) (e–h). (e,f) BPC 157 application at 15 min ligation-time, intragastric BPC 157 therapy, 1 min after application (e), or 5 min after application (f). (g,h) BPC 157 intragastric administration at 1 min ligation-time: 24 h ligation-time (g), 48 h ligation-time (h). Magnification ×200 ((a,c,e–g); scale bar 100 µm), ×200 ((b,d,h); scale bar 50 µm).