Figure 2.

Effect of HCRG21 on (a) paw edema and (b) TNF-α production (24 h after carrageenan administration). Negative control animals received a similar volume of saline. Positive control animals received indomethacin solution in a dose of 5 mg/kg. Intact animals (b) were not subjected to any manipulation. The reliability of differences was calculated by Student’s t-test (n = 7 for each group). The values * p < 0.05, ** p < 0.01 are considered reliable in comparison with negative control (PBS).